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NEWS & ANNOUNCEMENTS

CAGE Bio - September 2025

CAGE Bio Reports Strong Results from its Phase 2b Atopic Dermatitis Trial


The Phase 2b study enrolled 180 patients ≥12 years of age at 16 sites across the United States. A large majority of patients (~85%) had moderate AD, while 9% had mild and 6% had severe AD, all with affected body surface area <10%.

The trial met primary and secondary endpoints, demonstrating best-in-class treatment success, rapid itch reduction, and a favorable safety profile.

......[click link before for full article]

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RENIBUS - JUNE 2025

Renibus Therapeutics Announces FDA Orphan Drug Designation for Veverimer for the Treatment of Anti-glomerular Basement Membrane Disease (anti-GBM)


SOUTHLAKE, Texas, June 10, 2025 /PRNewswire/ -- Renibus Therapeutics® ("Renibus"), announced that the U.S. Food and Drug Administration (FDA) has granted Orphan Drug Designation to veverimer for the treatment of anti-glomerular basement membrane disease (anti-GBM), an ultra-rare life-threatening condition characterized by acute renal failure associated with the presence of auto-immune antibodies with affinity for the glomerular basement membrane.   ......[click link before for full article]

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RENIBUS - APRIL 2025

Renibus Therapeutics Announces Completion of Enrollment in PROTECT, a Pivotal Phase 3 Clinical Trial of RBT-1 to Reduce the Risk of Post-Operative Complications After Cardiac Surgery


SOUTHLAKE, Texas, April 24, 2025 /PRNewswire/ -- Renibus Therapeutics® ("Renibus"), a clinical late-stage biopharmaceutical company focusing on the prevention and treatment of cardiac, renal, and metabolic diseases, today announced the completion of enrollment (n=400) in PROTECT, a pivotal Phase 3 trial evaluating the effect of RBT-1 on reducing the risk of post-operative complications in patients undergoing cardiac surgery (NCT06021457). The trial enrolled 423 patients across 40 trial sites in the United States (US) and Canada. Topline results from the study are anticipated in third quarter of this year.......[click link before for full article]

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NANOSCOPE - October 2024

Nanoscope Announces Plans to Submit BLA for MCO-010 to Treat Retinitis Pigmentosa

Productive FDA meeting paves the way for BLA submission for MCO-010 in Q1 2025


DALLAS, TX — Oct. 10, 2024  — Nanoscope Therapeutics Inc., a late-stage clinical biotechnology company developing gene therapies for retinal degenerative diseases today announced a productive FDA meeting for its clinical program evaluating MCO-010 for the treatment of retinitis pigmentosa (RP). Based on the regulatory feedback provided in the meeting, Nanoscope will commence with submission of a Biologics License Application (BLA) in Q1 2025.......[click link before for full article]

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CAGE BIO - October 2024

Investor Capital Distribution


The inTUMO Therapeutics board has accepted an offer from a buyer to acquire all outstanding stock. The board of directors of Cage Bio did a spin-off of their Solid Tumor assets in May of 2022, and issued stockholders in Cage Bio their pro rata in inTumo Therapeutics, Inc. The “Solid Tumor Assets” were Cage assets that were  exclusively related to the research, development, and commercialization of assets with respect to oncology therapies employing tissue ablation via tumoral injection or catheter-based delivery of ionic liquids. As part of the transaction, CKG Management will be issuing a capital return to all investors that participated in the CJV, LLC and C2JV, LLC offerings. Investors in these entities should have already received a communication, but our encouraged to contact their CKG Management representative if they have not received any details.  

RENIBUS - July 2024

Cardiology and Heart Surgery

Preconditioning Drug Offers Potential to Reduce Side Effects of Cardiac Surgery


Despite advancements over the past several decades to help minimize the post-operative complications of cardiac surgery, many patients still experience an inflammatory response to cardiopulmonary bypass, when doctors use a heart-lung machine to continue to pump blood while the heart is arrested. This response can lead to prolonged ventilation, bleeding, stroke, and renal dysfunction, often increased time in the intensive care unit (ICU) and prolonged length of stay.....[click link before for full article]

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RENIBUS - April 2024

Novel Pre-op Agent Reduces Anemia, Transfusion in Cardiac Surgery Patients


The pharmacologic preconditioning agent RBT-1, a first-in-class drug for patients undergoing cardiothoracic surgery, reduces the incidence of anemia, blood transfusion and use of supplemental iron in these patients, according to research presented at the 2023 annual meeting of the American Society for Enhanced Recovery and Perioperative Medicine.

A combination of stannic protoporfin and iron sucrose, RBT-1 upregulates anti-inflammatory, antioxidant and iron-scavenging pathways. It was granted a Breakthrough Therapy designation by the FDA in July 2023, after results from a phase 2, double-blind, placebo-controlled trial in patients undergoing coronary artery bypass graft and/or cardiac valve surgery on cardiopulmonary bypass found significant improvement in clinically meaningful end points, including days in the ICU, ventilator time, hospital length of stay and cardiopulmonary.....[click link before for full article]

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NANOSCOPE - March 2024

Nanoscope Therapeutics Announces Positive Top-line Results from Randomized Controlled Trial of MCO-010 for Retinitis Pigmentosa


  • MCO-010 achieved its primary and key secondary endpoints with statistical significance and no serious adverse events 
  • Data from the Phase 2b RESTORE trial demonstrate clinically meaningful vision improvement in legally blind individuals with progressive and permanent neurodegeneration of the retina
  • RESTORE is the first randomized, controlled trial of a mutation-agnostic gene therapy for a genetic disease
  • Nanoscope anticipates submitting a Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) in the second half of 2024

DALLAS, March 26, 2024 /PRNewswire/ -- Nanoscope Therapeutics Inc., a late-stage clinical biotechnology company developing gene therapies for inherited retinal diseases and age-related macular degenerations (AMD), today announced positive top-line results after the completion of the 2-year Phase 2b RESTORE randomized, controlled clinical trial of its lead program, MCO-010, a mutation-agnostic gene therapy for patients with permanent and severe vision loss from advanced retinitis pigmentosa (RP). .....[click link before for full article]

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RENIBUS - MARCH 2024

Renibus Announces Leadership Transition


Jeffrey Keyser, RPh, JD, PhD, co-Founder and Former co-CEO, Appointed President & CEO 


SOUTHLAKE, Texas, March 21, 2024 /PRNewswire/ -- Renibus Therapeutics® ("Renibus"), a clinical-stage biopharmaceutical company focusing on the prevention and treatment of cardio-renal and metabolic diseases, today announced a transition in its leadership structure. As part of this change, Frank Stonebanks, former co-CEO, has left the company to pursue new opportunities.  Renibus wishes Mr. Stonebanks the best in his future endeavors. Jeffrey Keyser, RPh, JD, PhD, co-founder and former co-CEO, has been appointed President and CEO of Renibus.

Dr. Keyser is a veteran of the biopharmaceutical industry with a track record of success. Prior to co-founding Renibus, Dr. Keyser invented the Mucinex product line for Adams Respiratory Therapeutics, Inc. and co-founded ZS Pharma, Inc. (acquired by Astra Zeneca Plc).   His leadership has been instrumental in Renibus' success to date and he is well positioned to lead the company into its next phase of growth and innovation.

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NANOSCOPE - January 2024

Nanoscope Therapeutics Provides Regulatory Update on MCO-010 for the Treatment of Retinitis Pigmentosa


  • FDA and EU Regulators provide consistent advice that visual acuity may serve as primary endpoint to evaluate the effectiveness of MCO-010 in the treatment of low-vision retinitis pigmentosa (RP) patients 
  • Regulatory feedback provides clarity for potential path to approval in the US and in Europe for MCO-010 in RP; Nanoscope preparing for immediate execution


DALLAS, Jan. 18, 2024 /PRNewswire/ -- Nanoscope Therapeutics Inc., a late-stage clinical biotechnology company developing gene therapies for inherited retinal diseases and age-related macular degenerations (AMD), today provided an update following recent regulatory discussions with the U.S. Food and Drug Administration ("FDA") and from the Scientific Advice meeting with the ...regarding the regulatory path of MCO-010 for the treatment of RP .....[click link before for full article]

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RENIBUS - January 2024

Renibus Announces Publication of Results from Phase 2 Study Evaluating RBT-1 as a Pre-Conditioning Agent to Reduce Post-Operative Complications Following Cardiothoracic Surgery


increases the risk of post-operative complications

Phase 3 PROTECT study ongoing, top line data anticipated Q3 2025

SOUTHLAKE, Texas, Jan. 9, 2024 /PRNewswire/ -- Renibus Therapeutics® ("Renibus"), a clinical-stage biopharmaceutical company focusing on the prevention and treatment of cardio, renal and metabolic diseases, today announced publication in E-Clinical Medicine, part of The Lancet Discovery Science, of results from the Phase 2 study evaluating RBT-1, the Company's first-in-a-new-class preconditioning agent, under investigation to reduce post-operative complications.....[click link before for full article]

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NANOSCOPE - December 2023

Nanoscope Therapeutics Continues Leadership Growth; Welcomes Accomplished Finance and Biotech Leader Glenn Sblendorio as Chairman of the Board


DALLAS, Dec. 4, 2023 /PRNewswire/ -- Nanoscope Therapeutics (Nanoscope), a clinical-stage biotechnology company developing gene therapies for inherited retinal diseases, today announced the appointment of Glenn Sblendorio as Chairman of the Board, effective immediately. With more than 30 years of exemplary experience marked by extensive executive leadership in the ophthalmic industry, Mr. Sblendorio will support Nanoscope in reaching its strategic vision.............[click link below for full article]

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ONCONANO - November 2023

OncoNano Medicine Announces Positive Preclinical Data for ON-BOARD™ IL-12 Program at SITC 2023 Annual Meeting


SOUTHLAKE, Texas--(BUSINESS WIRE)--OncoNano Medicine, Inc. today presented positive preclinical data describing the effective delivery of interleukin-12 (IL-12) with the ON-BOARD™ platform technology at the 38th Annual Meeting of the Society for Immunotherapy of Cancer (SITC).

The study findings show that encapsulation of a therapeutic IL-12 fusion protein (IL-12Fc) for tumor specific delivery and pH-dependent activation was achieved using the ON-BOARD™ polymeric micelle technology. The study also found that ON-BOARD™ significantly improved the tolerability of IL-12Fc, as compared to unencapsulated IL-12. The encapsulated IL-12Fc demonstrated potent anti-tumor efficacy and durable anti-tumor memory in the MC38 colorectal cancer model. ONM-412, the development product candidate with the IL-12 encapsulated in the ON-BOARD™ polymeric micelle system, is advancing through IND-enabling activities............[click link below for full article]

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RENIBUS - October 2023

Renibus Announces First Patient Enrolled in PROTECT Phase 3 Study of RBT-1 to Reduce Post-operative Complications After Cardiothoracic Surgery


Pivotal trial will evaluate the effect of RBT-1 as a preconditioning agent in people undergoing cardiothoracic surgery


Estimated 600K CABG and valve repair surgeries in US/year, creating a large initial market for RBT-1


PROTECT enrollment on track, NDA filing anticipated early 2026


SOUTHLAKE, Texas, Oct. 25, 2023 /PRNewswire/ -- Renibus Therapeutics® ("Renibus"), a clinical-stage biopharmaceutical company focusing on the prevention and treatment of cardio-renal and metabolic diseases, today announced that the first patient has been dosed in the pivotal Phase 3 PROTECT trial of RBT-1, the Company's first-in-a-new-class preconditioning agent under investigation to reduce post-operative complications following cardiothoracic surgery. PROTECT is expected to be conducted at approximately 35 sites in the United States and Canada............[click link below for full article]

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RENIBUS - September 2023

Renibus Therapeutics Announces Final Close of Upsized Series B Financing, Bringing Total Round to $72 Million


SOUTHLAKE, Texas, Sept. 12, 2023 /PRNewswire/ -- Renibus Therapeutics, Inc., ("Renibus"), a clinical-stage biopharmaceutical company focusing on the prevention and treatment of cardio-renal and metabolic diseases, today announced the close of an extension to its Series B financing round, bringing the total amount raised to $72 million.   Renibus' investors are comprised of existing and new investors, including leaders in the cardiac surgery community............[click link below for full article]

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CAGE BIO - August 2023

CAGE Bio Announces Positive Topline Results From its Double-Blind Phase 2 Study Evaluating an Ionic Liquid formulation of 1% Tofacitinib In Patients with Atopic Dermatitis


SAN CARLOS, CA and FORT WORTH, TX / ACCESSWIRE / August 3, 2023 / CAGE Bio, Inc. (hereinafter "CAGE Bio") a biotechnology company focused on developing innovative drug therapies for localized treatment of immuno-dermatological disorders, today announced positive results from its randomized, vehicle controlled, phase 2 study evaluating the safety and efficacy of CGB-500, an ionic liquid formulation of 1% Tofacitinib, in patients with Atopic Dermatitis (AD)...........[click link below for full article]

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RENIBUS- July 2023

Renibus Therapeutics Announces $47 Million Financing to Advance Lead Program RBT-1 Through Pivotal Phase 3 Trial


SOUTHLAKE, Texas, July 18, 2023 /PRNewswire/ -- Renibus Therapeutics, Inc., ("Renibus"), a clinical-stage biopharmaceutical company focusing on the prevention and treatment of cardio-renal diseases, today announced raising $47 million from the initial closings of a Series B financing ..........[click link below for full article]

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RENIBUS- July 2023

Renibus Therapeutics Announces Breakthrough Therapy Designation from US FDA for RBT-1 for the Reduction in Risk of Post-Operative Complications in Patients Undergoing Cardiothoracic Surgery


SOUTHLAKE, Texas, July 11, 2023 /PRNewswire/ -- Renibus Therapeutics, Inc., ("Renibus"), a clinical-stage biopharmaceutical company focusing on the prevention and treatment of cardio-renal diseases, today announced that the U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy designation to RBT-1 for the reduction in risk of post-operative complications in patients undergoing cardiothoracic surgery, and confirmed its alignment with the Company's planned Phase 3 pivotal trial.  ..........[click link below for full article]

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RENIBUS- April 2023

Renibus Reports Positive Final Results from Phase 2 Study of RBT-1, a First-in-Class Preconditioning Agent for Patients Undergoing Cardiothoracic Surgery, at the American Association for Thoracic Surgery (AATS) Meeting


RBT-1 achieved the primary biomarker endpoint, as well as several key clinical outcome endpoints; positive data supports the potential for RBT-1 to improve postoperative outcomes in cardiothoracic surgery-


RBT-1 as a preconditioning agent has the potential to provide patient benefits in multiple surgical settings where organ injury during surgery increases the risk of post-operative complications-

-Planned pivotal Phase 3 study of RBT-1 to be initiated in June 2023-


SOUTHLAKE, Texas, May 7, 2023 /PRNewswire/ -- Renibus Therapeutics® ("Renibus"), a clinical-stage biopharmaceutical company focusing on the prevention and treatment of cardio-renal diseases, today presented positive final results from a Phase 2 trial evaluating RBT-1 (stannic protoporfin/iron sucrose) in patients undergoing elective cardiac surgery during an oral presentation..........[click link below for full article]

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NANOSCOPE - April 2023

Nanoscope Therapeutics Announces Presentation of Key Results from Phase 2b RESTORE Trial of MCO-010 for the Treatment of Retinitis Pigmentosa at the ARVO Annual Meeting


  • 100% (18/18) MCO-010 patients experienced a clinically meaningful improvement in vision-guided mobility (MLYMT), near-field object recognition (MLSDT) or visual acuity (BCVA) (p=0.007 vs sham)
  • 94.4% (17/18) MCO-010 patients showed vision improvement in the MLYMT or BCVA (p=0.008 vs sham)
  • 88.9% (16/18) of MCO-010 patients experienced a clinically meaningful 2 or more luminance level improvement in MLYMT or MLSDT (p=0.02 vs sham)
  • Favorable safety profile for MCO-010 with no serious or severe adverse event


DALLAS, April 27, 2023 /PRNewswire/ — Nanoscope Therapeutics Inc., a clinical-stage biotechnology company developing gene therapies for retinal degenerative diseases, today announced the presentation of key data from its Phase 2b multicenter, randomized, double-masked, sham-controlled RESTORE clinical trial. ..........[click link below for full article]

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NANOSCOPE - MARCH 2023

Nanoscope’s gene therapy nabs Phase II win in retinitis pigmentosa


In another win for the gene therapy space, Dallas, Texas-based Nanoscope Therapeutics announcedpositive topline data in a Phase IIb trial of MCO-010 in advanced retinitis pigmentosa.


The 27-patient Phase IIb RESTORE trial (NCT04945772) met its primary efficacy endpoint of the Multi-Luminance Y-mobility Test (MLYMT), which measures patients’ ability to navigate between LEDs lights in a room of varying luminance. In the study, 18 patients received MCO-010 while 9 received a sham intravitreal injection. ..........[click link below for full article]

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NANOSCOPE - MARCH 2023

Nanoscope Therapeutics Announces Positive Topline Results from Phase 2b RESTORE Trial of MCO-010 for the Treatment of Retinitis Pigmentosa


DALLAS, March 30, 2023 /PRNewswire/ -- Nanoscope Therapeutics Inc., today announced topline results from the Phase 2b multicenter, randomized, double-masked, sham-controlled RESTORE clinical trial (NCT04945772)  of MCO-010, an ambient-light activatable Multi-Characteristic Opsin (MCO) optogenetic therapy for vision restoration in advanced retinitis pigmentosa (RP), irrespective of gene mutation. MCO-010 has received both orphan drug and fast track designations from the U.S. Food and Drug Administration (FDA) ..........[click link below for full article]

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ONCONANO - MARCH 2023

OncoNano Medicine Presents Data from Phase 2 Pegsitacianine Study at Society of Surgical Oncology (SSO) 2023 International Congress on Surgical Cancer Care


SOUTHLAKE, Texas--(BUSINESS WIRE)--OncoNano Medicine, Inc. presented data from a Phase 2 study of pegsitacianine, a pH-sensitive fluorescent nanoprobe for image-guided cancer surgery, at the Society of Surgical Oncology (SSO) 2023 International Congress on Surgical Cancer Care, occurring March 22-25 in Boston, MA. Data from the study revealed that the primary endpoint was achieved in 50% of the evaluable patients undergoing peritoneal carcinomatosis surgery ..........[click link below for full article]

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RENIBUS - JANUARY 2023

Renibus Therapeutics Announces Oral Presentation on RBT-1 Phase 2 Results at 2023 Society of Critical Care Medicine (SCCM) Meeting


-RBT-1 met the primary biomarker endpoint as well as several key clinical endpoints; positive data supports the potential for RBT-1 to improve postoperative outcomes in cardiothoracic surgery-


-RBT-1 treatment demonstrated a statistically significant reduction in ICU days and 30-day cardiopulmonary readmission rates; patients treated with RBT-1 had reduced time on ventilator as well as reduced rates of atrial fibrillation, hypervolemia, acute kidney injury, troponin I levels and anemia, indicating a broad, organ protective effect consistent with the mechanism of action of RBT-1-


-SCCM has awarded a STAR Research Achievement Award to the presentation as a recognition of excellence in critical care research-


-Planned pivotal Phase 3 study of RBT-1 to be initiated in Q1 2023-


SOUTHLAKE, Texas, Jan. 19, 2023 /PRNewswire/ -- Renibus Therapeutics® ("Renibus"), a clinical-stage biotech company focusing on the prevention and treatment of cardio-renal diseases, today announced that an oral presentation will be delivered on the positive results of RBT-1 from a Phase 2 Study at the Society for Critical Care Medicine (SCCM) 2023 Critical Care Congress at the Moscone Center in San Francisco, CA from January 21- 24, 2023 ..........[click link below for full article]

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RENIBUS - JANUARY 2023

Renibus Therapeutics Announces Positive 30-Day Topline Data from RBT-1 Phase 2 Trial


SOUTHLAKE, Texas, Jan. 5, 2023 /PRNewswire/ -- Renibus Therapeutics® ("Renibus"), a clinical-stage biotech company focusing on the prevention and treatment of cardio-renal diseases, today announced positive 30-day topline data from RBT-1 in a Phase 2 trial. RBT-1 met the primary endpoint of increasomarkers of cytoprotective preconditioning in a multicenter, double-blind, placebo controlled, Phase 2 study in patients undergoing coronary artery bypass graft (CABG) and/or cardiac valve surgery on cardiopulmonary bypass. ..........[click link below for full article]

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ONCONANO - JANUARY 2023

OncoNano Medicine’s Pegsitacianine Granted Breakthrough Therapy Designation for Real-Time Surgical Imaging by the Food and Drug Administration


SOUTHLAKE, Texas--(BUSINESS WIRE)--OncoNano Medicine, Inc. today announced that its lead clinical development candidate, pegsitacianine, a pH-sensitive fluorescent nanoprobe for image-guided cancer surgery, has received Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) as an adjunct for the visualization of metastatic disease in the peritoneal cavity in patients undergoing cytoreductive surgery.........[click link below for full article]

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NANOSCOPE - OCTOBER 2022

Nanoscope Therapeutics Receives Fast Track Designation by the FDA for MCO-010 for the Treatment of Retinitis Pigmentosa


DALLAS, Oct. 10, 2022 /PRNewswire/ -- Nanoscope Therapeutics Inc., a clinical-stage biotechnology company developing gene therapies for retinal degenerative diseases, today announced that the U.S. Food and Drug Administration (FDA) has granted Fast Track Designation (FTD) to MCO-010, an ambient-light activatable Multi-Characteristic Opsin (MCO) optogenetic monotherapy to restore vision in blind patients, for the treatment of retinitis pigmentosa (RP) via intravitreal injection........[click link below for full article]

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ONCONANO - OCTOBER 2022

OncoNano Medicine Announces Positive Phase 2 Data for Pegsitacianine as an adjunct to Cytoreductive Surgery of Peritoneal Carcinomatosis


SOUTHLAKE, Texas--(BUSINESS WIRE)--OncoNano Medicine, Inc. today announced positive interim clinical results from an ongoing Phase 2 study of its lead clinical development candidate, pegsitacianine, for the detection of residual disease following cytoreductive surgery (CRS). Study results. were presented by Patrick Wagner, MD, Department of Surgical Oncology, Allegheny Health Network Cancer Institute, during an oral presentation at the World Molecular Imaging Congress (WMIC) in Miami, FL on September 29th.......[click link below for full article]

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CAGE BIO - SEPTEMBER 2022

CAGE Bio, TAGCyx, and PeptiStar Announce Execution of a License Agreement for Development and Commercialization of TAGX-0003 for the Treatment of Immunodermatology Diseases Mediated by the IFN-Gamma Pathway


SAN CARLOS, CA and FORT WORTH, TX / ACCESSWIRE / September 15, 2022 / CAGE Bio Inc. (hereinafter "CAGE Bio"), a biotechnology company focused on developing innovative therapies for infection, inflammation and immunology and TAGCyx Biotechnologies Inc. (hereinafter "TAGCyx"), a biotechnology company developing DNA aptamer drugs based on its proprietary artificial nucleic acid base pair technology, announce the execution of a license agreement for development of TAGX-0003 for the targeted treatment of alopecia areata and vitiligo by dermatological application......[click link below for full article]

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NANOSCOPE - SEPTEMBER 2022

Nanoscope Therapeutics Announces Completion of Enrollment in STARLIGHT Phase 2 Clinical Trial of MCO-010 Optogenetic Gene Therapy for Stargardt Disease


DALLAS, Sept. 13, 2022 /PRNewswire/ -- Nanoscope Therapeutics Inc., a clinical-stage biotechnology company developing gene therapies for retinal degenerative diseases, today announced full enrollment of its Phase 2 clinical trial of MCO-010, an ambient-light activatable Multi-Characteristic Opsin (MCO) optogenetic monotherapy to restore vision in blind patients, for Stargardt disease. Six-month data from the Phase 2 STARLIGHT trial are expected in H1 2023......[click link below for full article]

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RENIBUS - JUNE 2022

Renibus Therapeutics Announces Positive Interim Data from RBT-1 Phase 2 Trial


SOUTHLAKE, Texas, June 15, 2022 (GLOBE NEWSWIRE) -- Renibus Therapeutics® (“Renibus”), a clinical-stage biotech company focusing on the prevention and treatment of cardio-renal diseases, today announced that its lead-clinical candidate, RBT-1, met the primary endpoint of increasing the expression of biomarkers of cytoprotective preconditioning in a pre-specified interim Phase 2 data analysis. While the trial was not powered to demonstrate statistical significance beyond its primary endpoint.....[click link below for full article]

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RENIBUS - JUNE 2022

Renibus Therapeutics Expands Leadership Team, Announces Appointments of New Chief Financial Officer and Chief Medical Officer


SOUTHLAKE, Texas, June 02, 2022 (GLOBE NEWSWIRE) -- Renibus Therapeutics® (“Renibus”), a clinical-stage biotech company focusing on the prevention and treatment of cardio-renal diseases, today announced the expansion of its leadership team with the appointment of Jamie Donadio as Chief Financial Officer, and Bhupinder Singh, MD, as Chief Medical Officer. Both Mr. Donadio and Dr. Singh will report to Renibus’ Chairman and Chief Executive Officer (CEO), Frank Stonebanks. The addition of these seasoned biotech leaders comes at a critical time, as Renibus continues to scale and develop its portfolio of products that aim to transform both the prevention and treatment of kidney disease.....[click link below for full article]

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ONCONANO - MAY 2022

OncoNano Medicine Announces the Appointment of Elina Lavit as Vice President, Business Development 


SOUTHLAKE, Texas--(BUSINESS WIRE)--OncoNano Medicine, Inc. today announced the appointment of Elina Lavit as Vice President, Business Development. Mrs. Lavit brings over 18 years of experience in leadership roles in organizations ranging from start-ups to Fortune 100 corporations in various therapeutic areas, including oncology and surgery. At OncoNano, Mrs. Lavit will be responsible for driving strategic partnerships and business development activities to support the company’s continued growth.,.....[click link below for full article]

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RENIBUS - APRIL 2022

Renibus Therapeutics Strengthens IP Position with Additional US Patent 


Renibus Therapeutics granted patent approval for the novel aqueous iron composition of RBT-3, a product that targets prevention of cisplatin-induced nephrotoxicity


SOUTHLAKE, Texas, April 13, 2022 (GLOBE NEWSWIRE) -- Renibus Therapeutics® (“Renibus”), a clinical-stage biotech company focusing on the prevention and treatment of cardio-renal diseases, today announced that the United States Patent and Trademark Office (USPTO) has granted the addition of a new patent to its IP portfolio. The patent, No. 11,292,813, covers a novel aqueous iron composition of RBT-3,.....[click link below for full article]

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ONCONANO - APRIL 2022

OncoNano Medicine Announces Positive Preclinical Data for Tumor Specific Delivery with the ON-BOARD™ Platform at AACR 2022 Annual Meeting


SOUTHLAKE, Texas--(BUSINESS WIRE)--OncoNano Medicine, Inc. today announced positive results from the company’s ON-BOARD™ pH-sensitive nanoparticle platform. The data, presented at the American Association for Cancer Research (AACR) Annual Meeting 2022, demonstrate that the clinically validated ON-BOARD™ platform has the potential to be a universal tool for tumor specific activation and the efficient delivery of proteins for an improved therapeutic index. .....[click link below for full article]

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Nanoscope - January 2022

Nanoscope Awarded Key U.S. Patent Protecting its Multi-Characteristic Opsin Gene Therapy Platform For Reversing Blindness


BEDFORD, Texas, Jan. 10, 2022 /PRNewswire/ -- Nanoscope Therapeutics Inc, a clinical-stage biotechnology company developing optogenetic gene therapies for retinal degenerative diseases, today announced that Nanoscope has been awarded U.S. patent 11,180,537 covering its Multi-Characteristic Opsin (MCO) optogenetic gene therapy platform for restoring vision. This award bolsters Nanoscope's existing intellectual property position .....[click link below for full article]

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Cage - December 2021

Introducing New ionSURETM


Cage Bio introduces the commercialization of ionSURETM - Triple action hand wash that cleans hands, hydrates skin, and helps repel germs. In the pandemic, consumer’s hand hygiene routines are causing an irritating side effect – increasingly dry and chapped hands. Hand sanitizers keep out bugs but severely dehydrate skin.  Soap and water, while a gold standard, are not always convenient to use.  Patented ionic liquid technology, named as ionSENZTM differentiates ionSURETM from ordinary hand washes in that it works by forming a thin protective film that not only locks essential skin moisturizers in, but also helps repel germs.  No other hand wash provides such protection for total peace of mind. Visit myionSURE.com or Amazon to purchase.

Purchase on Amazon

ONCONANO - OCTOBER 25, 2021

OncoNano Announces $18.4 Million Equity Investment by the Cancer Prevention and Research Institute of Texas


SOUTHLAKE, Texas--(BUSINESS WIRE)--OncoNano Medicine, Inc. today announced that the Cancer Prevention and Research Institute of Texas (CPRIT) will convert $18.4 million in grant award funding into an equity investment in OncoNano. Proceeds of the financing will be used to support OncoNano’s Phase 3 clinical trials in the U.S. and Europe for pegsitacianine, an innovative real-time imaging agent used in intraoperative surgical resection of solid tumors, and accelerate the advancement of the company’s first internal therapeutic development program .... [ click link below for full article]

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ONCONANO - OCTOBER 8, 2021

OncoNano Medicine Announces Positive Preclinical Data for ONM-501 at AACR Virtual Conference on Tumor Immunology and Immunotherapy


SOUTHLAKE, Texas--(BUSINESS WIRE)-- OncoNano Medicine, Inc. announced positive results from its preclinical study of ONM-501, a novel dual-activating polyvalent STING agonist for immuno-oncology applications. The data, presented at The American Association for Cancer Research (AACR) Virtual Conference on Tumor Immunology and Immunotherapy, demonstrate strong efficacy in multiple tumor models .... [ click link below for full article]

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ONCONANO - SEPTEMBER 22, 2021

OncoNano Medicine Announces Expanded Research Collaboration With UT Southwestern Medical Center to Advance Development of New Cancer Therapies


SOUTHLAKE, Texas--(BUSINESS WIRE)--OncoNano Medicine, Inc., a clinical-stage company utilizing the principles of molecular cooperativity in drug design to exploit universal tumor and immune targets to diagnose and treat cancer, today announced a multi-year collaboration with The University of Texas Southwestern Medical Center (UTSW) to discover and conduct translational research of novel cancer therapeutics that leverage . ... [ click link below for full article]

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NANOSCOPE - SEPTEMBER 16, 2021

Biotech startup lands $1.5M grant funding on path to potentially going public


BEDFORD, Texas, September 16, 2021 /Bizjournals -- Nanoscope Therapeutics is on a mission to restore sight to those with age-related macular degeneration. And early trials of its therapy show it can do just that.

To help fuel its Phase 2b trials, the Bedford-based biotech startup announced landing a $1.5 million Small Business Research Innovation grant from the National Eye Institute as it looks to bring its optogenetic gene therapy. ... [ click link below for full article]

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NANOSCOPE - JULY 19, 2021

Nanoscope Therapeutics Announces First Patient Dosed in Phase 2b clinical trial of Optogenetic Gene Monotherapy to Restore Vision in Patients with Retinitis Pigmentosa


BEDFORD, Texas, July 19, 2021 /PRNewswire/ -- Nanoscope Therapeutics Inc., a clinical-stage biotechnology company developing gene therapies for treatment of retinal degenerative diseases, today announced that the first patient had been dosed in its Phase 2b clinical trial of MCO-010, an ambient-light activatable optogenetic monotherapy to restore vision in patients with retinitis pigmentosa (RP).e. ... [ click link below for full article]

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ONCONANO - JUNE 17, 2021

OncoNano Medicine Raises ~$50 Million in Series B Financing


Financing round led by Advantech healthcare investment team 

Funds will support Phase 3 program for pegsitacianine and IND-enabling activities for ONM-501


SOUTHLAKE, Texas--(BUSINESS WIRE)-- OncoNano Medicine, Inc. today announced the raise of an approximate $50 million Series B financing led by the healthcare investment team at Advantech Capital, a China-based cross border institutional investment fund. Proceeds of the financing will be used, in part, to support the Phase 3 clinical trials in the U.S. and Europe. ... [ click link below for full article]

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NANOSCOPE - JUNE 13, 2021

What Is ‘Optogenetics’? Behind The Technology That’s Bringing Sight To The Blind


Meanwhile, Texas-based biotech company Nanoscope Therapeutics is expected to begin a clinical trial of an opsin that responds to ambient light this summer. Nanoscope’s synthetic opsin molecule responds to a broad range of wavelengths, and the patients don’t require goggles, says Samarendra Mohanty, president of Nanoscope. 


In Nanoscope’s previous trial, conducted in India, 11 patients regained some vision beginning 4-6 weeks after receiving the injections, Mohanty says. Those gains have persisted for one year so far, he says. Some of the patients reportedly see well enough to use a cell phone, read large letters, and travel unassisted to the study center. ... [ click link below for full article]

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NANOSCOPE - JUNE 3, 2021

Nanoscope's Optogenetic Gene Therapy Restores Clinically Meaningful Vision in 11 Patients Blinded by Retinitis Pigmentosa


Nanoscope's RP gene therapy, which has received orphan drug designation from the US Food and Drug Administration, uses a proprietary AAV2 vector to deliver the MCO genes into the retina. This mutation-independent gene therapy involves a single injection through the eye administered in a doctor's office. 


  • First reported clinically meaningful functional improvement by optogenetic therapy 
  • Significant dose-dependent improvement of visual acuity at 16 weeks, previously reported at the American Academy of Ophthalmology 2020 annual meeting, continues through 52 weeks in severe retinitis pigmentosa patients
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CAGE - May 11, 2011

CAGE Bio Initiates Phase 2 Study for Treatment of Rosacea


CAGE Bio Inc., a biotechnology company focused on developing innovative therapies for infection, inflammation and immunology, announced dosing of the first patient in its Phase 2 clinical trial for the treatment of inflammatory lesions of rosacea.

The 12-week randomized double-blind vehicle-controlled trial is testing CAGE Bio's novel ionic-liquid based product CGB-400 Topical Gel. Patients diagnosed with moderate to severe rosacea with inflammatory lesions on their face will be enrolled in the study at four sites in the US and randomized to an active or vehicle arm.

 ... [ click link below for full article]

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RENIBUS - MARCH 11, 2021

Renibus Therapeutics Initiates Phase 2 Study of RBT-1 for Prevention of Acute Kidney Injury 


- The Phase 2 study will evaluate the efficacy of RBT-1 on acute kidney injury prevention in subjects undergoing cardiac surgery


Renibus plans to enroll 126 subjects at up to 20 sites across the United States, Canada, Australia, and New Zealand


DALLAS, Texas, March 11, 2021 (GLOBE NEWSWIRE) -- Renibus Therapeutics® (“Renibus”), a clinical-stage biotech company focusing on the prevention, treatment, and diagnostic testing of kidney disease, announced today that the company has initiated a Phase 2 study evaluating the efficacy of RBT-1 on acute kidney injury (AKI) prevention in subjects undergoing coronary artery bypass graft (CABG) and/or cardiac valve surgery. The study plans to enroll 126 patients in up to 20 sites across the United States, Canada, Australia ... [ click link below for full article]

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RENIBUS - FEBRUARY 16, 2021

Renibus Therapeutics Announces Publication of Positive Results of RBT-3 Experimental Preclinical Studies in Scientific Journal Nephrology Dialysis Transplant


RBT-3 found to reduce cisplatin-induced kidney toxicity by 50% in experimental preclinical model


- With no currently approved therapies for the prevention or treatment of platinum-induced toxicity, RBT-3 has the potential to fill a critical unmet medical need.


Dallas, Texas, Feb. 16, 2021 (GLOBE NEWSWIRE) -- Renibus Therapeutics, Inc., a clinical-stage biotech company focusing on the prevention, treatment, and diagnostic testing of kidney disease, announced today the publication of a peer-reviewed article in the scientific journal Nephrology Dialysis Transplant demonstrating that its investigational treatment for iron deficiency anemia, RBT-3, reduces cisplatin-induced kidney toxicity in an experimental preclinical model... [ click link below for full article]

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OncoNano - FEBRUARY 10, 2021

Study Reveals Compelling Data for a New Nanoparticle-based Immuno-Therapeutic to Treat Cancer


SOUTHLAKE, Texas--(BUSINESS WIRE)--OncoNano Medicine, Inc. today announced that a research paper titled “Prolonged activation of innate immune pathways by a polyvalent STING agonist” published in Nature Biomedical Engineering shows that a pH-sensitive nanoparticle-based drug developed by Dr. Jinming Gao and team at the University of Texas Southwestern Medical Center (UTSW) could boost the body’s innate immune pathways in the treatment of multiple cancers with a unique mechanism of activating the STimulator of INterferon Genes (STING). OncoNano licensed this technology from UTSW for further development as part of the company’s proprietary ... [ click link below for full article]

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NANOSCOPE - FEBRUARY 2, 2021

Nanoscope® team conferred Phase II Retinal Organoid Challenge (ROC) award by National Institute of Health


This is the second program based on Nanoscope's Multi-Characteristic Opsin Platform to receive orphan designation. This designation highlights the unmet need for therapy of patients with rare form of inherited macular degeneration.


BEDFORD, Texas, Feb. 2, 2021 /PRNewswire/ -- To meet the advance challenge for generating a physiologically relevant three-dimensional (3D) retinal organoid, Nanoscope researchers® in collaboration with University of Colorado, and Miami University were recently awarded the top prize from the 3D-ROC challenge by the National Institute of Health (NIH).... [ click link below for full article]

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NANOSCOPE - FEBRUARY 1, 2021

TechFW Client Nanoscope on Winning Team in National Eye Institute Challenge


With the eyes of the nation upon them, leading ophthalmic researchers at the University of Colorado, Miami University and those from Nanoscope® , led by Samarendra Mohanty, PhD, were recognized as the winning top research team of the 3D-ROC challenge by the National Eye Institute (NEI)..... [ click link below for full article]

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NANOSCOPE - JANUARY 25, 2021

Nanoscope Therapeutics Receives Orphan Drug Designation for gene therapy of blindness


This is the second program based on Nanoscope's Multi-Characteristic Opsin Platform to receive orphan designation. This designation highlights the unmet need for therapy of patients with rare form of inherited macular degeneration.


BEDFORD, Texas, Jan. 25, 2021 /PRNewswire/ -- NANOSCOPE THERAPEUTICS Inc., a clinical-stage biotechnology company determined to change lives through the ocular gene therapy, today announced that it has received an Orphan drug designation from FDA for gene therapy-based treatment of Stargardt disease, a form of inherited retinal degenerative disease caused by gene mutation and passed on to children.... [ click link below for full article]

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ONCONANO - NOVEMBER 9, 2020

OncoNano Announces Positive Preclinical Data for ONM-400 Tumor Specific IL-2 Delivery at the 2020 Society for Immunotherapy of Cancer (SITC) Annual Meeting


Findings indicate proof of mechanism and strong antitumor efficacy in preclinical models


SOUTHLAKE, Texas--(BUSINESS WIRE)-- OncoNano Medicine, Inc. today announced positive results from its preclinical study of ONM-400, a novel interleukin-2 (IL-2) encapsulating pH-activated nanoparticle that targets metabolic acidosis of cancer. ONM-400 employs OncoNano’s ON-BOARDTM platform designed to provide tumor specific delivery of a variety of cancer therapeutics. The data, presented today at the Society for Immunotherapy of Cancer (SITC) 35th Anniversary Annual Meeting, demonstrate successful tumor... [ click link below for full article]

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NANOSCOPE - OCTOBER 22, 2020

Scientists use gene therapy and a novel light-sensing protein to restore vision in mice


NIH-funded therapy will now be tested in humans.


October 22, 2020 – A newly developed light-sensing protein called the MCO1 opsin restores vision in blind mice when attached to retina bipolar cells using gene therapy. The National Eye Institute, part of the National Institutes of Health, provided a Small Business Innovation Research grant to Nanoscope, LLC for development of MCO1. The company is planning a U.S. clinical trial for later this year....[click link below for full article]

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ONCONANO - OCTOBER 7, 2020

OncoNano Announces Positive Clinical Data for Cancer Imaging Agent ONM-100 at The World Molecular Imaging Congress 


Findings indicate favorable tolerability and proof of mechanism in various solid tumors 


SOUTHLAKE, Texas – October 7, 2020 – OncoNano Medicine, Inc. today announced positive results from its ongoing Phase 2a study of ONM-100, an innovative imaging agent used in intraoperative surgical resection of solid tumors. The data, presented today at the World Molecular Imaging Congress (WMIC) Virtual 2020, demonstrate successful imaging of various solid tumors. .... [click link below for full article].

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CAGE BIO - JULY 23, 2020

Biotech Startup Discovers Novel Hand Sanitizer for COVID-19, Offering Long-lasting 4+ Hours of Protection


CAGE Bio Inc., today announced discovery of a novel hand sanitizer that offers long-lasting protection from coronavirus and other harmful viruses, bacteria, and fungi.  It kills germs on contact and, unlike common hand sanitizers, provides protection against their transmission for more than four hours after applying to skin.   .... [click link below for full article].

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NANOSCOPE THERAPEUTICS - JULY 20, 2020

TechFW client closes Series A funding round, names Guillem chairman


Nanoscope Therapeutics, a TechFW client, has closed an over-subscribed Series A funding round for its leading work on retinas, which could improve sight for the blind. In addition, Nanoscope has named Al Guillem, Chairman of the Board. Guillem was part of TechFW success story ZS Pharma, a company he co-founded, was purchased by AstraZeneca for $2.7 billions  .... [click link below for full article].

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CAGE BIO - JULY 7, 2020

Biotech Startup Announces R&D Collaboration with Major Japanese Drug Delivery Company


SAN CARLOS, Calif., July 7, 2020 /PRNewswire/ -- CAGE Bio Inc. today announced a research and development agreement with Nitto Denko Corporation for a transdermal formulation of undisclosed molecules. The goal of the partnership is to explore the potential for developing therapeutic products at Nitto using CAGE Bio's proprietary deep eutectic ionic liquid technology. Under this agreement, the companies  .... [click link below for full article].

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RENIBUS THERAPEUTICS - June 23, 2020

Renibus Therapeutics Receives FDA Fast Track Designation for RBT-9 Treatment in COVID-19


DALLAS, Texas, June 23, 2020 (GLOBE NEWSWIRE) -- Renibus Therapeutics, Inc., a clinical-stage biotechnology company, announced today that it has been granted Fast Track designation by the FDA for RBT-9 treatment in COVID-19. 

“Obtaining Fast Track designation will be instrumental in expediting the development of RBT-9 for patients with COVID-19, especially those at increased risk of developing complications,” .... [click link below for full article].

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OncoNano Medicine - June 26, 2020

OncoNano Announces Publication of ONM-100 Phase 1 Data in Nature Communication


Publication data suggests ONM-100 was safe and provides preliminary feasibility data for use in resection surgery in 4 diverse tumor types 

SOUTHLAKE, Texas- OncoNano Medicine, Inc. announced today the publication of Phase 1 clinical trial data in Nature Communications featuring OncoNano’s intraoperative tumor imaging product candidate, ONM-100. The study evaluated safety, pharmacokinetics and feasibility of ONM-100 in image-guided surgery, occult tumor detection and visualization of tumor margins in four different cancer types. Following tumor resection, ONM-100 detected residual tumor positive margins in 9 of 9 patients in whom histology confirmed tumor positive margins, and also detected occult lesions in an additional 5 patients whose tumors were undetected by standard of care. ..[click the link below for full article]. 

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ONCONANO - FEBRUARY 1, 2021

OncoNano Medicine Announces Martin Driscoll as Chief Executive Officer


OUTHLAKE, Texas--(BUSINESS WIRE)-- OncoNano Medicine, Inc. today announced the appointment of Martin Driscoll as Chief Executive Officer and a member of the company’s Board of Directors. An accomplished industry veteran with multiple decades of biopharmaceutical development and commercialization experience, Mr. Driscoll most ...... [ click link below for full article]

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